TLR7 and coronary artery disorder: Moreover, we also measured the s-RNY expression in 263 sera of patients with CAD and 514 sera from age-matched control individuals.1 Biostatistical analysis positioned s-RNYs as relevant novel independent diagnostic biomarkers for CAD.1 The findings we are presenting here reveal for the first time that both intracellular or extracellular s-RNYs increase inflammation and cell death in lipid-laden macrophages by activating TLR7.