The major defects in the sperm include the absence of acrosomes, round sperm heads, and an aberrant arrangement of mitochondrial sheaths, which represent the prominent features of the human disease globozoospermia.29 In the GM130-deficient mouse model, only a small electron dense acrosome matrix and a very thin layer of acrosome sac were observed in the early stage spermatids, and the acrosome structure was completely absent at the later stages. The gene discussed is GOLGA2; the disease is Globozoospermia.