PARP1 and dry age related macular degeneration: PARP-1 is highly conserved, especially in the contiguous 50-amino-acid sequence, the signature motif of PARP, in the catalytic domain, which displays 100% conservation in vertebrates and the most abundantly expressed isoforms among the PARP family members, supporting the importance of PARP-1.30, 31, 32, 58, 59 Therefore, our data support the use of PARP-1 as a target for the treatment of dry AMD.