SQSTM1 and neurodegenerative disease: p62, also called sequestosome 1 (SQSTM1), possesses a short LC3 interaction region that facilitates direct interaction with LC3 and causes p62 degradation by autophagy.36, 37, 38 p62 is known to accumulate in cytoplasmic and nuclear ubiquitinated protein aggregates in various neurodegenerative diseases.39 As p62 degradation depends on autophagy, the level of p62 protein is another indicator of autophagic flux.40