APOE and age-related macular degeneration: APOE is synthetized by RPE and is one component of drusen.52 It has been shown that human fetal RPE cultured on porous membranes can secrete deposits that are rich in APOE and that exposure to serum could further result in accumulation of drusen components.53 This cell culture system mimics drusen formation and could be used for investigating AMD molecular mechanisms.