NFE2L2 and age-related macular degeneration: Similarly, increased flavoprotein fluorescence, suggesting elevated mitochondrial dysfunction, has been observed in nonexudative eyes with AMD.45 A recent study showed that a marine n-3 polyunsaturated fatty acid that induces a transient increase in cellular ROS levels in RPE activates the oxidative stress response regulator NFE2L2/NRF2 and simultaneously increases intracellular protein aggregates containing p62 and autophagy.46