SQSTM1 and age-related macular degeneration: Studies have shown direct control of mitochondrial function by mTOR69 with inhibition of mTOR enhancing aerobic glycolysis.69 In addition, p62 is suggested to be a key regulator of nutrient sensing in this pathway 70 with overexpression favoring more efficient activation of the mTOR pathway.70 Our observed increased p62 levels during starvation in AMD RPE could impact mTOR activity.