NFKB1 and sclerosing cholangitis: Thus, depletion of cIAP-1 and cIAP-2 can promote TRAIL-mediated inflammation via activation of non-canonical NF-κB pathway.17 Hence, cIAP depletion can result in either enhanced apoptosis and/or RelB/p52-dependent inflammation, and one or both of these pathways could cause sclerosing cholangitis.