Furthermore, in various cancer cells, Survivin is critically regulated by some cell signaling molecules, such as HIF-1α, PI3K/AKT, mTOR and AMPK.16, 17, 18 Therefore, we hypothesized that the expression of Survivin is sensitive to nutritional status and is regulated by nutrient-sensing pathways in adipocytes. The gene discussed is HIF1A; the disease is cancer.