We found association between (1) schizophrenia and reduced HTR2A mRNA expression; (2) schizophrenia and hypermethylation of HTR2A promoter CpG sites (cg5, cg7 and cg10); and (3) schizophrenia and HTR2A genotypes for rs6314 and rs6313. The gene discussed is HTR2A; the disease is schizophrenia.