SETD2 and acute lymphoblastic leukemia: There also appear to be more reports on the role of histone modifications and histone-modifying or chromatin-readers genes in T-cell ALL (with prominent reports on DNMT3A, TET1, EZH2 (enhancer of zeste 2 polycomb repressive complex 2), SUZ12 (SUZ12 polycomb repressive complex 2 subunit), MLL2, SETD2 (SET domain containing 2), PHF6 (PHD finger protein 6) and BRD4 (bromodomain containing 4)), despite its relatively low frequency, than in BCP-ALL, and there is little overlap between the T-cell ALL and BCP-ALL data [25,26,27,28,29,30].