SLC12A5 and autism: Changes in KCC2 function may account for many GABAergic signaling deficits, as it has been shown to be involved in the pathogenesis of epilepsy, schizophrenia, autism and aging brain (Ben-Ari et al., 2012; Ferando et al., 2016; Tang et al., 2016; Tao et al., 2012).