Using goblet cell‐like LS174T colon carcinoma cells which produce MUC2 glycoproteins (van Klinken et al., 1996), we found that EHEC O157:H7 prototype strains adhered better to this cell line compared to mucus‐deficient Caco‐2 and HT‐29 cells. This evidence concerns the gene MUC2 and colon carcinoma.