Moreover, when assessing for COX-2 genetic alterations (gene amplification, mRNA and protein up-regulation) in the various breast cancer subtypes using cBioportal (http://cbioportal.org) online application, we found the basal-like subtype to display the highest rate of COX-2 amplifications, compared to HER2 and luminal subtypes (Fig. 1e). This evidence concerns the gene ERBB2 and breast cancer.