First, we found that acute (1 and 7 days) pilocarpine-induced seizure activity, a well-established model of temporal lobe epilepsy [TLE27], significantly down-regulated NEAT1 expression (Fig. 4c), consistent with our findings in iPSC-derived neurons where NEAT1 was also down-regulated upon acute stimulation. Here, NEAT1 is linked to temporal lobe epilepsy.