MAP4K2 and autoimmune polyendocrinopathy: In this experiment, when compared with control group, the mRNA expression levels of three of the four target genes in APS group showed significant changes (P < 0.05, Fig. 9), including mitogen-activated protein kinase kinase 2 (MAP2K2), interferon gamma receptor 2 (IFNGR2), and mitogen-activated protein kinase kinase 1 (MAP2K1).