Moreover, expression of TNFα from these cells could mediate receptor/ligand-mediated lysis and the production of IFNγ could aid in sensitizing tumor cells to receptor-mediated lysis.34–36 The second population would constitute those CD8+ T cells that were HPV specific and harbored lytic potential as well as the ability to degranulate as evidenced by being positive for CD107a. This evidence concerns the gene TNF and neoplasm.