CD8A and neoplasm: Moreover, expression of TNFα from these cells could mediate receptor/ligand-mediated lysis and the production of IFNγ could aid in sensitizing tumor cells to receptor-mediated lysis.34–36 The second population would constitute those CD8+ T cells that were HPV specific and harbored lytic potential as well as the ability to degranulate as evidenced by being positive for CD107a.