Before this experiment, we expected that the Mig-6d/d mice should have impaired glucose homeostasis because the Mig-6d/d mice were reported to have hepatomegaly [16] and there were many reports that inhibitors of EGFR signaling pathway, gefitinib, improved the glucose intolerance or insulin resistance in human and experimental animal. The gene discussed is EGFR; the disease is Glucose intolerance.