MAPT and Alzheimer disease: Recent researches on animal models either of AD, VaD, or human neuroblastoma cells have shown that l-NBP achieves, through reduction of amyloidogenic Aβ, increase of alpha amyloid precursor protein (α-APP) levels (a product of α-secretase that is essential in the production of nonamyloidogenic Aβ) and its effect on tau hyperphosphorylation levels and inhibitory effects on neurofibrillary tangles formation, resulting in suppression of neurofibrillogenesis [55].