In this process, dendritic cells (DCs) maturation can be suppressed by changes in the cytokine balance (increased VEGF, TGFβ, IL-10, IL-6, and COX-2 and reduced IL-4, IL-12, IFN-α, and IFN-γ) within the tumor, which significantly impairs the antigen presenting function of these cells [8]. This evidence concerns the gene VEGFA and neoplasm.