Studies in preclinical breast cancer mouse models demonstrated that trastuzumab (monoclonal antibody against HER2) and cetuximab (monoclonal antibody to EGFR/HER-1) both have an important role in tumoral innate and adaptive immunity, inducing natural killer (NK) cells and cytotoxic as well as Th1 T-lymphocytes activity [137–140]. Here, EGFR is linked to breast cancer.