Bcl-2, a mitochondrial membrane-associated protein, is a target of miR-181 that mediates miR-181a-mediated Neuro-2a cell death upon oxidative stress [14], miR-181a-triggered mitochondrial dysfunction and astrocyte death upon glucose deprivation [9], and miR-181d-induced glioma cell apoptosis [23]. The gene discussed is BCL2; the disease is central nervous system cancer.