More specifically, previous investigations into the function of miR-324-3p were limited, and only several reports showed miR-324-3p was a target of ACE inhibition to promote renal fibrosis and miR-324-3p could target RelA promoter to induce its expression in an Ago2 dependent manner in cells of neural origin [19, 20]. Here, AGO2 is linked to renal fibrosis.