Studies in genetically modified mice and in human tumors found that altered expression of selected pro- (MCP-1, IFN-γ) and/or anti-inflammatory cytokines (IL-4, IL-10, and TGF-β1) had a crucial role in the promotion of gastric, colorectal, liver, breast, and skin carcinoma development [23]. This evidence concerns the gene IL4 and skin carcinoma.