In the multivariate COX PH analysis, SPARC expression (Hazard ratio (HR) = 1.835, P = 0.022), surgical procedure (HR = 0.296, P = 0.024), T stage (HR = 3.032, P = 0.005), and N-stage (HR = 3.866, P = 0.002) were revealed independent indicators for OS, and the prognostic model for GC were further validated using 1000 times bootstrapping (Table 3). Here, SPARC is linked to gastric cancer.