SPARC and neoplasm: Yet remarkably, the unique matricellular glycoprote Secreted Protein Acidic and Rich in Cysteine (SPARC) is gaining increasing attention, either for its extensive biological effect on tumor development, invasion, metastasis, angiogenesis and inflammation by mediating cell-microenvironment interaction [3], or for the predictive potential for the efficacy of nanoparticle albumin-bound (NAB) chemotherapy drugs via inducing drug accumulation [4].