Univariate Cox regression analysis confirmed the relevance of CUBN as good prognostic marker for overall survival (Table 3, HR 0.411, 95% CI 0.263–0.641, P < 0.001), and ccRCC-specific survival (Additional file 7: Table S6, HR 0.334, 95% CI 0.199–0.569, P < 0.001). This evidence concerns the gene CUBN and nonpapillary renal cell carcinoma.