ENPP2 and breast angiosarcoma: Based on the ROC curve, the optimal cutoff values of ATX methylation for overall, CpG 1, CpG 2, CpG 3, and CpG 4 as a possible biomarker for discriminating BA patients were projected to be 63.63, 63.50, 62.50, 63.50, and 63.50, respectively, which yielded the sensitivity of 81.60%, 63.20%, 81.60%, 65.80%, and 84.20% and the specificity of 60.00%, 63.10%, 51.60%, 50.80%, and 53.80%, respectively.