ENPP2 and breast angiosarcoma: Fig 1 illustrates a schematic representation of four CpG sites within the ATX gene promoter region. Overall, methylation levels at the ATX promoter were significantly lower in the BA group than healthy controls (P<0.0001). Similarly, BA patients demonstrated significantly reduced methylation levels when compared to healthy controls across four CpG sites, as follows: CpG 1: P = 0.0029, CpG 2: P = 0.0005, CpG 3: P = 0.0057, and CpG 4: P<0.0001 (Fig 2A).