Subsequent analysis illustrated that DNMT1 mRNA expression was inversely correlated with ATX methylation (r = -0.37, P<0.0001) (Fig 5C) but DNMT1 mRNA expression was positively correlated with ATX mRNA expression in peripheral blood leukocytes of BA patients (r = 0.51, P<0.0001) (Fig 5D). The gene discussed is DNMT1; the disease is breast angiosarcoma.