The clinical syndrome associated with GBA2 mutations was characterized either as an autosomal recessive cerebellar ataxia (ARCA) with spasticity or complicated hereditary spastic paraplegia (HSP) with ataxia: the latter is also known as spastic paraplegia 46 [SPG46 (MIM #614409)] [2,3]. Here, GBA2 is linked to hereditary spastic paraplegia.