In fact, studies showed an increase in ABCB1 and ABCC2 protein expression in endothelial cells from temporal lobe blood vessels of patients with refractory MTLE [6, 7], and a higher ABCB1 protein activity was observed in hippocampus of patients with pharmacoresistant temporal lobe epilepsy [8]. This evidence concerns the gene ABCB1 and temporal lobe epilepsy.