SOD2 and chronic kidney disease: Crawford et al. (2012) [16] reviewed 79 studies addressing a potential link between the SOD2 Val16Ala genotype and various diseases or disorders, and almost half of those studies reported relationships with various types of cancers, e.g. gastric, lung, prostate, bladder and breast, to diabetes type I, nephropathy, chronic kidney disease, and to chemotherapy responses.