NOD2 and colonic disorder: In particular, carriers of at least one NOD2 mutations [P = 2.1e-7, OR 2.9 (1.9–4.3)], were at risk for the colonic disease, as well as the carriers of mutations in rs10761659 (ZNF365) [P = 6.6e-4, OR 2.1 (1.4–3.1)] and those in rs10000113 (IRGM) [P = 2.8e-4, OR 2.0 (1.4–3.0)].