MTMR3 and Cowden disease: Similarly, carriers of the variations rs1000113 and rs4958847 in the IRGM gene and of the rs713875 polymorphism of the MTMR3 gene, were at an increased risk for ileal CD: [P = 6.0e-5, OR 2.0 (1.5–2.9)], [P = 0.005, OR 1.6 (1.1–2.2)] and [P = 0.003, OR 1.8 (1.2–2.7)], respectively.