AMPK has been shown to increase the expression of tumor suppressor genes including F-box and WD repeat domain containing 7 (FBXW7), semaphorin III/F (SEMA3F), and p21Cip1 (p21) in gastric cancer cells, and RORα functions a transcription activator [14, 17]. The gene discussed is FBXW7; the disease is gastric cancer.