HAND2 and central nervous system cancer: Several cancer associated lncRNAs including the common ceRNA hubs like HAND2-AS1 (DEIN) [44, 45] and RP11-276H19.1 [46], as well as subtype-specific hubs like ADAMTS9-AS2, a luminal A specific hub lncRNA, acted as tumor suppressors and inhibited the migration of the glioma cells [47].