We also identified 25 protein coding genes among the 28 subtype common ceRNA hubs, of which 12 (RECK, LHFP, FSTL1, TGFBR2, EBF1, ERG, MRVI1, DKK3, GAS7, RBMS3, PDGFRA and CCDC80) were listed as cancer related genes in the Cancer Gene Census (CGC) of the COSMIC database or the Genetic Association Database (GAD) [32, 33]. The gene discussed is RECK; the disease is cancer.