In order to understand if sPTPRJ expression can directly influence proliferation and if it could be a soluble protein able to bind membrane receptors and influence cell proliferation, we analyzed the cell proliferation of HUVEC cells and glioblastoma ADF and A172 cell lines infected with Ad5-GFP, Ad5-sPTPRJ (generation and testing of sPTPRJ recombinant adenovirus are reported in Materials and Methods) or Ad5-PTPRJ [36]. The gene discussed is PTPRJ; the disease is glioblastoma.