This evidence was further confirmed by the findings that RLYE inhibited in vitro angiogenesis in HUVECs stimulated with VEGF-A, but not with VEGFR-1-specific ligands (PlGF and VEGF-B), and that the peptide did not inhibit VEGF-A-induced proliferation and migration of MM cell lines that expressed only VEGFR-1. Here, VEGFB is linked to Miyoshi myopathy.