ESR2 and Hodgkins lymphoma: To elucidate the role of ERβ ligation in HL growth, we first investigated whether ERβ activation by the agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN) could affect cell proliferation and cycle progression in human HL cell lines, i.e., B-cell HL L-428 and KM-H2 and T-cell HL L-540 and HDLM-2.