FRET efficiency clearly showed a negligible molecular association between DRAM2 and LC3 in untreated cells and a highly significant molecular interaction in DPN-treated cells (Figure 5C, p < 0.001), suggesting that DRAM2 - LC3 binding plays a crucial role in ERβ-mediated autophagy induction in HL cells. Here, DRAM2 is linked to Hodgkins lymphoma.