We observed the rs3757328 in ZNRD1-AS1 was significantly associated with an increased risk of some cancer types (HCC, lung cancer, and bladder cancer) except cervical cancer (occurs only in women) both in the recessive model (Figure 1A, Recessive model: OR = 1.79; 95% CI = 1.33 – 2.41, P = 0.569 for the heterogeneity test, I2 = 0.0%) and additive genetic model (Figure 1B, Additive: OR = 1.15; 95% CI = 1.05–1.25, P = 0.507 for the heterogeneity test, I2 = 0.0%). Here, POLR1H is linked to hepatocellular carcinoma.