In particular, C1 (Chromosomal Instability (CIN)ImmuneDown), C3 (KRAS-mutant) and C5 (CINWntUp) molecular subtypes of CRC showed a mild but statistically significant increase in ESRP1 expression compared to the other subtypes (supplementary Figure 1B) [22]. This evidence concerns the gene KRAS and colorectal carcinoma.