Epithelial Splicing Regulatory Protein 1 (ESRP1) is an epithelial cell-specific RBP and splicing factor, which was first identified as a tumor suppressor in the colon adenocarcinoma cell line, LS180, due to its ability to bind to the 5′UTR of several cancer-related genes and regulate their translation [12]. The gene discussed is ESRP1; the disease is colon adenocarcinoma.