From this list, 8 novel top candidate genes were selected based on their display of highly cancer-specific hypermethylation over multiple adjacent promoter-associated DMCs: COL4A6, CYBA, HLF, LINC0134 (LOC149234), LRRC4, PROM1, RHCG, and TCAF1 (FAM115A) (Figure 2B, S1 and S2, Table S3). This evidence concerns the gene LRRC4 and cancer.