Together, these data indicate that COL4A6, CYBA, HLF, LINC01341, LRRC4, PROM1, RHCG, and TCAF1 are frequent targets of hypermethylation in prostate cancer, and that aberrant promoter hypermethylation contributes to downregulation of 6 of these genes in this malignancy. Here, PROM1 is linked to Familial prostate cancer.