Among the 80 tumor-tissue TKI-sensitizing EGFR M+ patients, the median PFS of the 49 plasma EGFR M+ patients was 334 days (95% CI: 317.0-351.0), whereas that of the 31 cfDNA EGFR M- patients was 420 days (95% CI: 100.1-739.9), indicating no significant difference between the groups (P = 0.145, Figure 4C). Here, EGFR is linked to neoplasm.