QPCR and Western blot analysis confirmed that EZH2 inhibition using UNC1999 downregulated IRF-4, XBP-1, BLIMP-1 and c-MYC at the mRNA (Figure 1B) and protein (Figure 1C) levels in all MM cell lines tested in this study. The gene discussed is PRDM1; the disease is Miyoshi myopathy.