Since VHL mutant cells affected apoptosis rather than cell proliferation, we treated the cells both with Camptothecin, a chemotherapeutic drug that stabilizes and activates p53 by inducing DNA damage and decreases cell proliferation and Sunitinib, a TKI which negatively influences cell proliferation and is used to treat ccRCC. Here, VHL is linked to nonpapillary renal cell carcinoma.