We show that bortezomib administration in tumor-bearing mice modulates the levels of immunostimulatory cytokines IL-2, IL-12, and IL-15 and enhances their downstream signaling by increasing the expression of their receptors on tumor-infiltrating CD8+T cells in endogenous or adoptive HA518-526-specific CD8+T cell transfer set ups resulting in reduced pulmonary metastatic nodules. The gene discussed is IL2; the disease is neoplasm.