In our previous study, we found that miR-149 is significantly downregulated in 5-FU resistant CRC cells, and restoration of miR-149 could reverse the resistance of CRC cells to 5-FU by directly targeting FOXM1 [35], suggesting the role of FOXM1 in the 5-FU resistance of CRC cells. This evidence concerns the gene FOXM1 and colorectal carcinoma.