At 24 hours after injection of 123I-scFvD2B, no accumulation for all examined tissues was recorded in non-tumor-bearing mice (Figure 3A), while preferential uptake of 123I-scFvD2B in PSMA-positive tumors (%ID/g mean ± SD = 0.14±0.03) was observed in animals engrafted with LNCaP cells (Figure 3B). The gene discussed is FOLH1; the disease is neoplasm.