Anderson randomly assigned 16 patients to receive propranolol 80 mg/d or placebo plus beclometasone 100 ug/d, and the results showed that histamine PC20 was unchanged and exhaled nitric oxide, blood eosinophils, serum eosinophilic cationic protein and asthma quality-of-life questionnaire symptoms were worsened by adding propranolol to beclometasone, which was further demonstrate by Short48, 49, 50. The gene discussed is RNASE3; the disease is asthma.