β-adrenoreceptor (βAR) agonists, especially β2-adrenoreceptor agonists, are the most common use bronchodilators in asthma treatment, and inhaled long-acting β2 agonists (LABA) are mainly used for long-term maintenance of symptoms relief as controller medications, of which salmeterol and formoterol account for the majority1. Here, ADRB2 is linked to asthma.