In previous studies from our laboratory using a bone marrow transplantation strategy as a first approach to examine a potential role of the macrophage Trpc3 in atherosclerosis, we found that the advanced aortic plaques of hyperlipidemic mice with bone marrow-selective deletion of Trpc3 have less necrosis and reduced number of apoptotic macrophages than control animals, parameters usually indicative of more stable plaques4. The gene discussed is TRPC3; the disease is atherosclerosis.