As we can see from Table 1, high mRNA expression of S100A7 (HR = 1.66, 95%CI: 1.04–2.65, p = 0.0326), S100A8 (HR = 1.82, 95%CI: 1.13–2.92, p = 0.0117), S100A9 (HR = 2.13, 95%CI: 1.32–3.46, p = 0.0016) and S100A12 (HR = 1.65, 95%CI: 1.02–2.65, p = 0.0375) were associated with worse OS in grade II breast cancer. This evidence concerns the gene S100A12 and breast cancer.