Our results suggest that the inconsistently upregulated CYP2E1 or the lack of significant correlation between CYP2E1 levels and NASH or the CYP2E1 variant allele (CYP2E1*5) and NASH as discussed34, should not automatically exclude the involvement of CYP2E1, based on the clearly different levels of hepatic fibrosis between the WT and the corresponding Cyp2e1-null mice fed the same AIN-76A Western FF. This evidence concerns the gene CYP2E1 and metabolic dysfunction-associated steatohepatitis.