In addition, hepatic CB1 receptor, critical for the development of HFD-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice as demonstrated by using WT and liver specific CB1-null mice fed HFD26, was found to be consistently lower in Cyp2e1-null-FF, suggesting a potential interplay between CB1 and CYP2E1 in the regulation of lipid homeostasis in response to diet rich in fat and cholesterol. This evidence concerns the gene INS and metabolic syndrome.