Eight genes related to kidney toxicity, including kidney failure (CASP1, FCGR2A, FCGR2B, TLR2, TLR4, P = 0.003), damage of renal tubule (TLR2, TLR4, P = 0.01), proximal tubular toxicity (CTSS, LYZ, SLC22A5, P = 0.007) and their expression across 6 datasets were not confounded by tissue types (Fig. 3A–H). The gene discussed is CASP1; the disease is kidney failure.