Interestingly, we found that 72% (29 out of 40) of patients with normal colons exhibited high levels of nuclear VGLL4 (++ and +++) in their colons, whereas only 48% (29 out of 60) of patients with CRC had high nuclear expression of VGLL4 in the cancerous samples from their colons (Fig. 1a,b). Here, VGLL4 is linked to colorectal carcinoma.