To explore the role of VGLL4 as a tumour suppressor with more rigorous clinical data and with more CRC samples, the colon cancer patient dataset GSE14333 available in the Gene Expression Omnibus (GEO) Database (http://www.ncbi.nlm.nih.gov/gds) was employed32. The gene discussed is VGLL4; the disease is malignant colon neoplasm.