INS and obesity due to melanocortin 4 receptor deficiency: Among the functions of adiponectin, we can include the increased use of fattyacids in lean tissues, inhibition of atherosclerosis, hepatic fibrosis andglucose production by the liver, as well as a potential anti-inflammatory action(Meier & Gressner, 2004; Metwally et al., 2008).Those levels are decreased in obesity (Gil-Campos et al., 2004; Brewer & Balen, 2010), and that decrease is related tothe decrease in insulin sensitivity (Gosman etal., 2006), with RI and hyperinsulinemia (Meier & Gressner, 2004).