LEP and obesity due to melanocortin 4 receptor deficiency: But it seems to play a vitalrole in the connection between obesity and HPG, regulating the onset of puberty,modulating the reproductive capacity and facilitating the implantation andpregnancy (Oliveira & Lemos, 2010).In relation to the ovary, it is believed that leptin can affect the menstrualcycle through a direct inhibitor effect on the developing follicles.