In fact, the role of HOXB13 in prostate cancer development remains highly controversial, since it has been suggested to act both as an oncogene and as a tumor suppressor gene (TSG), and its role seems to be dependent on the cell type and on the cellular environment (androgen stimulation and androgen receptor (AR) status) [4,18,20,31,34]. The gene discussed is AR; the disease is prostate cancer.