Although in general we have not observed a dramatic phenotypic impact of HOXB13 mutants (except for A128D in anchorage independent growth), the expression levels induced in our cell models are equivalent to those found in the tumors of our prostate cancer series (including the tumor from a HOXB13 A128D mutation carrier), which lead us to infer that the established in vitro models would reproduce the HOXB13-dependent tumor biology. The gene discussed is HOXB13; the disease is Familial prostate cancer.