RSV also demonstrated inhibitory effect on NF-κB activity and ameliorated the elevated levels of inflammatory proteins, TNF-α (tumour necrosis factor-α), interleukin- (IL-) 6, and COX-2 (cyclooxygenase 2), thus contributing to reduction in neuroinflammation and protection against functional and behavioural deficits in diabetic neuropathy [106]. This evidence concerns the gene PTGS2 and diabetic neuropathy.